PT-141 10mg

PT-141 (Bremelanotide)

• Form: Lyophilized powder
• Purity: >99%

Overview

PT-141, also known as Bremelanotide, is a synthetic cyclic heptapeptide originally derived as a metabolite of Melanotan 2 (MT-II). It functions as an agonist of melanocortin receptors, particularly MC3R and MC4R. Unlike compounds targeting vascular systems directly, PT-141 acts primarily through central mechanisms in the brain, influencing physiological processes related to sexual function, energy balance, and metabolism.

Research Background

Melanocortin hormones and their analogs have long been studied for their roles in regulating sexual behavior, appetite, and energy expenditure. PT-141 emerged from studies on Melanotan peptides when researchers observed elevated sexual behavior in test animals. Unlike sildenafil and similar compounds, PT-141 appears to work centrally by stimulating neural pathways associated with arousal, rather than by acting directly on vascular tissues.

Mechanism of Interest

• MC3R activation: Suggested to influence hypothalamic activity linked to energy homeostasis, appetite control, and metabolic regulation.
• MC4R activation: Thought to play a key role in sexual arousal, appetite suppression, and energy expenditure; activation in penile tissue may promote nitric oxide (NO) release, supporting erectile function.
• Central nervous system activity: Animal studies report increased neuronal activation in the hypothalamus and surrounding CNS regions associated with arousal responses.
• NO pathway involvement: Research suggests possible involvement of the NO–cyclic GMP pathway in the melanocortin agonist–induced increase in cavernosal pressure.

Molecular Information

• Molecular Formula: C50H68N14O10
• Molecular Weight: 1025.18 g/mol
• Other Names: Bremelanotide