GHK-Cu (Copper Peptide)

GHK-Cu

• Form: Lyophilized powder
• Purity: >99%

Overview

GHK-Cu is a naturally occurring copper-binding tripeptide composed of three amino acids: glycyl-L-histidyl-L-lysine. The “-Cu” designation refers to its chemical binding with copper. GHK-Cu is found in human plasma and is typically released at the time of injury, where it is thought to play a role in wound healing and tissue repair. Concentrations of GHK-Cu decline with age, from an average of 200 ng/mL at age 20 to approximately 80 ng/mL by age 60.

Research Background

In cell culture studies, nanomolar concentrations of GHK-Cu have been observed to induce a wide range of cellular responses, from growth stimulation to differentiation. The peptide also demonstrates chelating properties, binding copper ions and small amounts of iron. Research suggests that the GHK-Cu complex may maximize biological activity when bound to these metals.

GHK-Cu has also been studied for its potential role in gene expression regulation. Some findings suggest it may help reset elements of the genome, potentially restoring function in impaired cells, including those affected by carcinogenesis or chronic disease processes such as COPD.

Mechanism of Interest

• Skin health: May help tighten and thicken aging skin, support extracellular matrix structure, and improve barrier function.
• Wound repair: Studied for its role in tissue regeneration and anti-inflammatory activity.
• Hair growth: May stimulate increased hair follicle size and activity.
• Antioxidant properties: Suggested to mitigate oxidative damage.
• Gene modulation: Potential role in resetting gene expression toward healthier cellular function.

Molecular Information

• Molecular Formula: C14H23CuN6O4
• Molecular Weight: 340.38 g/mol
• Other Names: Glycyl-L-histidyl-L-lysine-copper (2+)