Sermorelin 10mg

Sermorelin

• Form: Lyophilized powder
• Purity: >99%

Overview

Sermorelin is a synthetic 29-amino acid peptide, representing the shortest fragment of growth hormone–releasing hormone (GHRH) that retains biological activity. It is classified as GHRH (1–29) amide and has been widely studied for its ability to stimulate pituitary secretion of growth hormone (hGH). First explored in the early 1980s, Sermorelin was developed as a growth hormone secretagogue for models of growth hormone deficiency.

Research Background

Sermorelin was designed to mimic the natural GHRH peptide, which contains 44 amino acids. By utilizing the first 29 amino acids, researchers created a peptide that maintained activity at GHRH receptors while being shorter and more stable. Animal studies demonstrated that Sermorelin could stimulate pituitary growth hormone release, leading to subsequent production of insulin-like growth factor 1 (IGF-1).

Mechanism of Interest

• GHRH receptor activation: Sermorelin binds to GHRH receptors on pituitary somatotrophs, triggering the release of growth hormone.
• Pulsatile GH release: Unlike exogenous GH, Sermorelin supports natural rhythmic GH secretion, potentially reducing endocrine disruption.
• IGF-1 elevation: GH stimulation leads to increased IGF-1 levels, which mediate many anabolic effects of growth hormone.
• Endocrine selectivity: Research suggests Sermorelin does not significantly alter prolactin, insulin, cortisol, glucose, or thyroid hormone levels.

Molecular Information

• Peptide Length: 29 amino acids
• Half-life: ~11–12 minutes
• Other Names: GHRH (1–29) amide, GHRF (1–29)