Thymosin Beta-4 (TB-500) 10mg

TB-500 (Thymosin Beta-4 Synthetic)

• Form: Lyophilized powder
• Purity: >99%

Overview

TB-500, also known as synthetic Thymosin Beta-4 (Tβ4), is a 43-amino acid peptide designed to mimic the naturally occurring protein Thymosin Beta-4, which is encoded by the TMSB4X gene. Found abundantly in blood platelets and wound fluid, Thymosin Beta-4 has been studied for its potential involvement in cell migration, angiogenesis, wound healing, and tissue repair. TB-500 is the laboratory-produced version of this protein, created for controlled research applications.

Research Background

Thymosin Beta-4 naturally plays a role in cellular repair and regeneration. Researchers have suggested TB-500 may demonstrate similar properties, including anti-inflammatory effects and potential support for neurological healing, cardiac tissue repair, epidermal recovery, and spinal cord regeneration. Its high solubility and small molecular size may contribute to its mobility within tissues, making it a target of interest in regenerative research.

Mechanism of Interest

• Actin interaction: TB-500 includes the segment (17)LKKTETQ(23), considered the active site for actin binding. By binding to globular actin (G-actin), it may regulate the cytoskeleton and facilitate cell migration and wound healing.
• Actin sequestration: Proposed to increase the pool of G-actin by inhibiting filamentous actin (F-actin) formation, possibly affecting cell motility and tissue remodeling.
• Angiogenesis: Suggested to promote the formation of new blood vessels, potentially aiding tissue recovery and repair.
• Intracellular and extracellular roles: Detected both within cells and in plasma, TB-500 may influence cellular energy and motility via interaction with ATP synthase enzymes at the cell surface.

Molecular Information

• Amino Acid Sequence: Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH
• Molecular Formula: Noted as C₂₂₀H₃₅₀N₅₆O₇₈S
• Molecular Weight: ~4,925 g/mol
• Other Names: Thymosin Beta-4, Tβ4